Turkish Journal of Chemistry
Abstract
In our work, a new non-peripheral zinc(II) phthalocyanine bearing octa carboxylic acid ethyl ester derivative substituted triazole attached propylmercaptothiobenzylmercapto derivative was synthesized by the tetramerization reaction of phthalonitrile. The photochemical in vitro photodynamic activity of zinc(II) phthalocyanine (ZnPc-I), such as human non-small cell lung carcinoma cell lines, was investigated in this study. The singlet oxygen generation property of novel zinc(II) phthalocyanine (ZnPc-I) was also examined due to the significantly high singlet oxygen quantum yield of ZnPc-I (ΦΔ = 0.66). The antiproliferative effects of ZnPc-I were also investigated on A549 and H1299 cell lines, our results demonstrate that the ZnPc-I has a strong antiproliferative effect on both cell lines.
Author ORCID Identifier
YASEMİN YILDIZ: 0000-0003-3776-9633
NİLGÜN KABAY: 0000-0002-0661-6135
BURAK YILDIZ: 0000-0001-8283-3230
İPEK ÖMEROĞLU: 0000-0002-7528-0911
MAHMUT DURMUŞ: 0000-0003-0440-7345
E. RIZA KARAGÜR: 0000-0003-2189-8553
HAKAN AKÇA: 0000-0002-9477-8571
ÇAĞRI ERGİN: 0000-0001-7783-8723
YAŞAR GÖK: 0000-0001-8679-2149
DOI
10.55730/1300-0527.3699
Keywords
Photodynamic therapy (PDT), singlet oxygen, in vitro investigation, click reaction, zinc phthalocyanine
First Page
800
Last Page
808
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
YILDIZ, YASEMİN BAYĞU; KABAY, NİLGÜN; YILDIZ, BURAK; ÖMEROĞLU, İPEK; DURMUŞ, MAHMUT; KARAGÜR, E. RIZA; AKÇA, HAKAN; ERGİN, ÇAĞRI; and GÖK, YAŞAR
(2024)
"Synthesis, characterization, and investigation of photochemical and in vitro properties of novel Zn(II) phthalocyanine,"
Turkish Journal of Chemistry: Vol. 48:
No.
6, Article 2.
https://doi.org/10.55730/1300-0527.3699
Available at:
https://journals.tubitak.gov.tr/chem/vol48/iss6/2
