An efficient one-pot and simple multicomponent approach to the synthesis of highly functionalized furans containing dialkyl phenol

Authors

Fourogh Jalili MILANIFollow
Mahmoud NASSIRIFollow
Jaber SALEHZADEHFollow

DOI

10.55730/1300-0527.3649

Abstract

In this study, arylglyoxals, acetylacetone, and 2,6-dimethyl phenol or 2,6-di-tert-butyl phenol are combined to efficiently synthesize a series of 1-(4-(3,5-dialkylphenyl)-2-methyl-5-phenylfuran-3-yl) ethan-1-one derivatives in excellent yields. These reactions were carried out in acetone at reflux under catalyst-free conditions in the presence of triethylamine as a base for 3 h. NMR, FT-IR, EI-MS, and elemental studies were used to characterize the products' structural characteristics. The present study has also several benefits, such as excellent yields and the ease of workup procedure, making it an appealing, practical, and acceptable one-pot method for producing functionalized derivatives of dialkyl furan.

Keywords

One-pot reaction, furans, heterocycles, multicomponent reactions, arylglyoxals

First Page

176

Last Page

183

Recommended Citation

MILANI, Fourogh Jalili; NASSIRI, Mahmoud; and SALEHZADEH, Jaber (2024) "An efficient one-pot and simple multicomponent approach to the synthesis of highly functionalized furans containing dialkyl phenol," Turkish Journal of Chemistry: Vol. 48: No. 1, Article 16. https://doi.org/10.55730/1300-0527.3649
Available at: https://journals.tubitak.gov.tr/chem/vol48/iss1/16