Twelve compounds with a 1,5-diaryl-1-penten-3-one structure were synthesized and their cytotoxic activities were evaluated. The 1,5-diaryl-1-penten-3-one compounds were obtained via in situ enaminations of 4-phenyl-2-butanone and 4-(4-hydroxyphenyl)-2- butanone in the presence of pyrrolidine-AcOH, followed by condensation with six different benzaldehydes. The synthesized compounds were tested for their cytotoxic activity against human glioblastoma (U87-MG), breast (MCF-7), and prostate (PC-3) cancer cell lines. Some of the novel compounds exhibited remarkable cytotoxic action, especially against MCF-7 cancer cells.
1, 5-Diarylpentanoid, cytotoxic activity, breast cancer, prostate cancer, glioblastoma, anticancer effect
ÇELEBİOĞLU, NESLİHAN; TOZLU, ÖZLEM ÖZDEMİR; TÜRKEZ, HASAN; and SEÇEN, HASAN
"Synthesis of alnustone-like diarylpentanoids via a 4 + 1 strategy and assessment of their potential anticancer activity,"
Turkish Journal of Chemistry: Vol. 47:
5, Article 29.
Available at: https://journals.tubitak.gov.tr/chem/vol47/iss5/29