Turkish Journal of Chemistry
Abstract
In this paper, Cys-graft-p(HEMA) nanomaterials and a new electrochemical method were developed for determination of CA 125. Cys-graft-p(HEMA) nanomaterials were synthesized with emulsion polymerization method and modified with grafting procedure. It was determined that Cys-graft-p(HEMA) nanomaterials had 50 nm dimension and spherical morphology, and per gram polymeric material contained 0.011 mmol L-cysteine. Electrode surface was prepared step by step for electrochemical analysis with optimization process. Linear determination range was determined as 5-400 U/mL (R= 0.9935). Detection limit (LOD) was calculated as 1.87 U/mL, and quantification limit (LOQ) was determined as 5.62 U/mL. The fabricated sensor system showed good repeatability, accuracy, reality, and storage stability. According to the results obtained, Cys-graft p(HEMA) nanomaterials that is used for the first time in biosensor has the potential to find use in the sector with rapid determination time (10 min), extensive determination range, accuracy of methods. Novelties of this study are rapid analysis, determination range, appropriate of prototype device development, and developing new designed material. Developed material and method can be used in the preliminary diagnosis of the disease and combined with a prototype device that can allow the follow-up of the treatment process in diagnosed patients.
DOI
10.55730/1300-0527.3524
Keywords
Cys-graft-p(HEMA) nanomaterials, CA 125, electrochemical determination, point of care (POC)
First Page
137
Last Page
147
Recommended Citation
TÜRKCAN, CEREN and AKGÖL, SİNAN
(2023)
"Polymeric nanoparticle-based electrochemical sensor for the detection of CA 125,"
Turkish Journal of Chemistry: Vol. 47:
No.
1, Article 15.
https://doi.org/10.55730/1300-0527.3524
Available at:
https://journals.tubitak.gov.tr/chem/vol47/iss1/15