Turkish Journal of Chemistry
Intrinsically fluorescent and quercetin loaded highly crosslinked polyphosphazene nanospheres: synthesis, characterization and fluorescence properties
Highly crosslinked, inorganic-organic hybrid and intrinsically fluorescent polyphosphazene nanospheres bearing hydroxyl groups on the surface are facilely generated via a one-pot polycondensation of octachlorocyclotetraphosphazene, fluorescein and quercetin. The resulting nanospheres were characterised by scanning electron microscopy (SEM), energy-dispersive X-ray analysis (EDX), Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), X-ray diffraction analysis (XRD) and ultraviolet-visible spectroscopy (UV-vis) techniques. The average diameter of the nanospheres was determined as 379 nm. Also, quercetin which is both a monomer and an anticancer drug was loaded to the nanospheres as 446 mg g-1. The obtained nanospheres possess outstanding disperse ability in both aqueous and organic solvents. Moreover, the nanospheres exhibited intrinsically fluorescence intensity and outstanding photobleaching stability under ultraviolet-visible irradiation, due to the highly crosslinked and inorganic-organic hybrid structure. Owing to these superior properties and novelty of synthesized nanospheres, they have a great potential in many applications such as fluorescent labels, sensors, cell imaging and as a nanocarrier of quercetin for cancer treatment.
Fluorescence, phosphazene, highly crosslinked, inorganic-organic hybrid, fluorescein, quercetin
ÖRÜM, SİMGE METİNOĞLU
"Intrinsically fluorescent and quercetin loaded highly crosslinked polyphosphazene nanospheres: synthesis, characterization and fluorescence properties,"
Turkish Journal of Chemistry: Vol. 46:
4, Article 29.
Available at: https://journals.tubitak.gov.tr/chem/vol46/iss4/29