Antimicrobial and lipase inhibition of essential oil and solvent extracts of Cota tinctoria var. tinctoria and characterization of the essential oil

Authors

İSHAK ERİK
GÖZDE BOZDAL
SILA ÖZLEM ŞENER
BÜŞRA KORKMAZ
ŞENGÜL ALPAY KARAOĞLU
SALİH TERZİOĞLU
NURETTİN YAYLI

DOI

10.55730/1300-0527.3430

Abstract

The essential oil (EO) of Cota tinctoria var. tinctoria was analyzed using GC-FID / MS. A total of 51 compounds were determined from this taxon, accounting for 99.79% in hydrodistillation. Monoterpenes were the primary chemical class for the volatile organic compounds in the EO (36.1%, 13 compounds). Borneol (18.1%), camphor (14.9%), and β-pinene (11.3%) were the major components in the EO of C. tinctoria var. tinctoria. The antimicrobial activities of EO and n-hexane, acetonitrile, methanol, and water solvent extracts of the taxon were screened in vitro against ten microorganisms. The EO yielded the best activity (15 mm, 372.5 MIC, 59600 μg/μL) against Mycobacterium smegmatis. The acetonitrile extract was the most active against the Staphylococcus aureus and Bacillus cereus with 274 μg/mL MIC value. IC50 values for the lipase enzyme inhibitory activity of EO and solvent extracts (n-hexane, acetonitrile, methanol, and water) were found to be 59.80 ± 4.3285 μg/mL 68.28 ± 3.1215 μg/mL, 52.60 ± 3.7526 μg/mL, 48.73 ± 2.8265 μg/mL, and 99.50 ± 5.5678 μg/mL, respectively.

Keywords

Antimicrobial, Cota tinctoria var. tinctoria, GC-FID/MS, lipase inhibition, volatile compounds

First Page

1234

Last Page

1244

Recommended Citation

ERİK, İSHAK; BOZDAL, GÖZDE; ŞENER, SILA ÖZLEM; KORKMAZ, BÜŞRA; KARAOĞLU, ŞENGÜL ALPAY; TERZİOĞLU, SALİH; and YAYLI, NURETTİN (2022) "Antimicrobial and lipase inhibition of essential oil and solvent extracts of Cota tinctoria var. tinctoria and characterization of the essential oil," Turkish Journal of Chemistry: Vol. 46: No. 4, Article 26. https://doi.org/10.55730/1300-0527.3430
Available at: https://journals.tubitak.gov.tr/chem/vol46/iss4/26