Thio-Schiff bases derived from 2,2'-disulfanedianiline via nanocerium oxide: antimicrobial effect and antiproliferative effects in melanoma cells

Authors

ASLIHAN DALMAZ
SEFA DURMUŞ
GÖRKEM DÜLGER
MERVE ALPAY

DOI

10.55730/1300-0527.3414

Abstract

In this study, the synthesis of dimeric disulfide-Schiff bases was carried out using two methods. The structures of the obtained Schiff bases were elucidated by various spectroscopic methods as well as elemental analysis. The Schiff base derivative compounds (3a-6) were screened for in vitro antibacterial activity against multidrug-resistant microorganisms using microdilution method. All the tested compounds showed varying inhibition zones against the pathogens. According to MIC results, the compound 2 was shown strong inhibitory activity against all the tested microorganisms compared to antibiotics. In addition, all the tested compounds showed different antiproliferative effects on the melanoma cell line (B16F10). Our synthesized dimeric disulfide-Schiff bases have shown significant various effects.

Keywords

Schiff base, nanocatalyst CeO2, antimicrobial activity, cytotoxicity, antiproliferative, melanoma

First Page

1055

Last Page

1068

Recommended Citation

DALMAZ, ASLIHAN; DURMUŞ, SEFA; DÜLGER, GÖRKEM; and ALPAY, MERVE (2022) "Thio-Schiff bases derived from 2,2'-disulfanedianiline via nanocerium oxide: antimicrobial effect and antiproliferative effects in melanoma cells," Turkish Journal of Chemistry: Vol. 46: No. 4, Article 10. https://doi.org/10.55730/1300-0527.3414
Available at: https://journals.tubitak.gov.tr/chem/vol46/iss4/10