Turkish Journal of Chemistry
Article Title
DOI
10.55730/1300-0527.3377
Abstract
Several 5-(alkylsulfonyl)-1-substituted-2-(1H-pyrrol-2-yl)-1H-benzo[d]imidazole derivatives were synthesized and their antioxidant activities were investigated using lipid peroxidation (LPO) and 7-ethoxyresorufin O-deethylase (EROD) assays. Docking analysis with Human NAD[P]H-Quinone oxidoreductase 1 (NQO1) was also performed to gather thorough information about these compounds that have antioxidant activities. Moreover, their molecular descriptors and ADME properties were calculated using the SwissADME online program. As a result, most of our compounds possessed better affinity and created ample interactions with NQO1. The most potent compound 5j had LP inhibition value of 3.73 nmol/mg/min. Other compounds exhibited moderate activity on LP levels comparing to standard butylated hydroxy toluene (BHT). However, the inhibitory effect on EROD activity was not significant.
First Page
890
Last Page
902
Recommended Citation
KARADAYI, FİKRİYE ZENGİN; BAŞARAN, RAHMAN; KIŞLA, MEHMET MURAT; EKE, BİNAY; and ALAGÖZ, ZEYNEP
(2022)
"Synthesis, antioxidant activity, molecular docking and ADME studies of novel pyrrolebenzimidazolederivatives,"
Turkish Journal of Chemistry: Vol. 46:
No.
3, Article 23.
https://doi.org/10.55730/1300-0527.3377
Available at:
https://journals.tubitak.gov.tr/chem/vol46/iss3/23
