Antiinflammatory photodynamic therapy potential of polyoxyethylene-substituted perylene diimide, nitrocatechol, and azo dye

Authors

ÖZGÜL HAKLI
KASIM OCAKOĞLU
FURKAN AYAZ

DOI

10.3906/kim-2104-8

Abstract

Photodynamic therapy (PDT) applications enable light-controlled activation of drug candidates instead of their constitutive activities to prevent undesired side effects associated with their constant activities. A specific wavelength of light is utilized to enable electron mobility in the chemical structure, which results in differential activities that may alter cell viability and cellular functions. Canonical photodynamic therapy applications mostly focus on cytotoxicity-based antimicrobial and anticancer properties of the PDT agents. In this study, we focused on subtoxic concentrations of three different molecules containing polyoxyethylene group and examined their antiinflammatory activities on stimulated mammalian macrophages. Stimulated macrophages produce proinflammatory cytokines TNF and IL6. In the presence of a light source, our PDT agents were activated for 5 and 10 min during their application to the macrophages. Based on the ELISA results, the compounds had anti-inflammatory PDT activities. Trypan blue staining results suggest that these derivatives exerted their activities without leading to cytotoxicity. Our results suggest noncanonical PDT applications of these derivatives that can alter cellular activities without leading to cell death.

Keywords

Inflammation, perylene, photodynamic therapy, macrophages, antiinflammatory compounds

First Page

1752

Last Page

1760

Recommended Citation

HAKLI, ÖZGÜL; OCAKOĞLU, KASIM; and AYAZ, FURKAN (2021) "Antiinflammatory photodynamic therapy potential of polyoxyethylene-substituted perylene diimide, nitrocatechol, and azo dye," Turkish Journal of Chemistry: Vol. 45: No. 6, Article 7. https://doi.org/10.3906/kim-2104-8
Available at: https://journals.tubitak.gov.tr/chem/vol45/iss6/7