A four-component modified Biginelli reaction: A novel approach for C-2 functionalizedDihydropyrimidines

Authors

HARSHA NARKHEDE
AVINASH DHAKE
VAIDHYANATHAN BALASUBRAMANIYAN

DOI

10.3906/kim-2105-59

Abstract

A novel four component modified Biginelli reaction for the synthesis of C-2 functionalized dihydropyrimidines has been established. The approach uses assembly of less explored acetyl acetone with aromatic aldehyde, thiourea, and dimethyl sulphate to construct a novel 5-acetyl 2-methylthio dihydropyrimidine system, which works as an efficient well-designed intermediate for generating C-2 modified Biginelli libraries with nitrogen nucleophiles. Phenyl hydrazine, semicarbazide, and aryl semicarbazides are successfully used as N-nucleophiles to generate C-2 functionalized dihydropyrimidine derivatives, which fulfil the demands of active pharmacophore. Time economy, step economy, and a single pot reaction with moderate to excellent yield are the major advantages of this novel method. Key words:

Keywords

Biginelli reaction, green synthesis, 4-MCR, 2-Methylthio-1, 4-DHPMs, N- nucleophiles

First Page

1980

Last Page

1987

Recommended Citation

NARKHEDE, HARSHA; DHAKE, AVINASH; and BALASUBRAMANIYAN, VAIDHYANATHAN (2021) "A four-component modified Biginelli reaction: A novel approach for C-2 functionalizedDihydropyrimidines," Turkish Journal of Chemistry: Vol. 45: No. 6, Article 26. https://doi.org/10.3906/kim-2105-59
Available at: https://journals.tubitak.gov.tr/chem/vol45/iss6/26