Novel vic-dioximes: synthesis, structure characterization, and antimicrobial activity evaluation

Authors

DUMITRU URECHE
ION BULHAC
ALEXANDRU CIOCARLAN
DANIEL ROSHCA
LUCIAN LUPASCU
PAULINA BOUROSH

DOI

10.3906/kim-2104-24

Abstract

The vic-dioximes are compounds with various industrial uses and scientific applications. Many coordination compounds have been synthesized based on vic-dioximes. This study presents the synthesis and full characterization of two vic-dioximes based on dichloroglyoxime, p-aminobenzoic acid, and p-aminotoluene. Their structures were proved by IR, 1H, 13C and 15N NMR spectral analysis, and single crystal X-ray diffraction. One of the reported vic-dioximes, bis(di-p-aminotoluene)glyoxime mono-p-aminotoluene trihydrate showed good to moderate antimicrobial activity against both nonpathogenic gram-positive and gram-negative bacteria (Bacillus subtilis and Pseudomonas fluorescens), phytopathogenic (Xanthomonas campestris, Erwinia amylovora, E. carotovora) and the fungi (Candida utilis and Saccharomyces cerevisiae) at MIC - 70-150 μg/mL.

Keywords

vic-dioxime, spectral analysis, X-ray diffraction, antibacterial activity, antifungal activity

First Page

1873

Last Page

1881

Recommended Citation

URECHE, DUMITRU; BULHAC, ION; CIOCARLAN, ALEXANDRU; ROSHCA, DANIEL; LUPASCU, LUCIAN; and BOUROSH, PAULINA (2021) "Novel vic-dioximes: synthesis, structure characterization, and antimicrobial activity evaluation," Turkish Journal of Chemistry: Vol. 45: No. 6, Article 18. https://doi.org/10.3906/kim-2104-24
Available at: https://journals.tubitak.gov.tr/chem/vol45/iss6/18