Turkish Journal of Chemistry
Synthesis of imidazo-1,4-oxazinone derivatives and investigation of reaction mechanism
In this study, nine different C-2 aroyl imidazole derivatives were synthesized in a one pot reaction with two steps, and the reduction reactions of these derivatives with NaBH4 were carried out under mild conditions. Substitution reaction of obtained imidazo methanol derivatives with chloroacetylchloride reagent and ring reaction of substitution products were investigated. It was determined that 1,4-imidazoxazinone derivative was obtained as a result of the cyclization reaction. The intermediate products obtained during the cyclization reaction were isolated, and the path of the reaction under different conditions was discussed.
Cyclization, imidazole, imidazoxazinone
"Synthesis of imidazo-1,4-oxazinone derivatives and investigation of reaction mechanism,"
Turkish Journal of Chemistry: Vol. 45:
5, Article 28.
Available at: https://journals.tubitak.gov.tr/chem/vol45/iss5/28