In this study, hydroxy benzoin (1-7), benzil (8-14), and benzoin/benzil-O-β-D-glucosides (15-25) were synthesized to investigate their biological activities. An efficient method for synthesizing hydroxy benzoin compounds (1-7) was prepared from four different benzaldehydes using an ultrasonic bath. Then, antioxidant (FRAP, CUPRAC, and DPPH), antimicrobial (3 Gram (-), 4/6 Gram (+), one tuberculosis and one fungus), and enzyme inhibition (acetylcholinesterase, butyrylcholine esterase, tyrosinase, α-amylase, and α- glucosidase) for the all synthesized compounds (1-25) were evaluated. And also, four most active compounds (4, 12, 18a+b, and 25) from each group were evaluated to the human cervical cancer cell line (HeLa) and anticancer screening tests against the human retinal normal cell line (RPE). Compound 4 showed HeLa and RPE cancer cell activities as much as cisplatin. The synthesized compounds were characterized by spectroscopic methods (NMR, FT-IR, UV, LC-QTOF-MS) and the ACD NMR program's help.
YAYLI, NURETTİN; KILIÇ, GÖZDE; ÇELİK, GONCA; KAHRİMAN, NURAN; KANBOLAT, ŞEYDA; BOZDEVECİ, ARİF; KARAOĞLU, ŞENGÜL ALPAY; ALİYAZICIOĞLU, REZZAN; SELLİTEPE, HASAN ERDİNÇ; DOĞAN, İNCİ SELİN; and AYDIN, ALİ
"Synthesis of hydroxy benzoin/benzil analogs and investigation of their antioxidant,antimicrobial, enzyme inhibition, and cytotoxic activities,"
Turkish Journal of Chemistry: Vol. 45:
3, Article 23.
Available at: https://journals.tubitak.gov.tr/chem/vol45/iss3/23