Turkish Journal of Chemistry
Abstract
In this study, hydroxy benzoin (1-7), benzil (8-14), and benzoin/benzil-O-β-D-glucosides (15-25) were synthesized to investigate their biological activities. An efficient method for synthesizing hydroxy benzoin compounds (1-7) was prepared from four different benzaldehydes using an ultrasonic bath. Then, antioxidant (FRAP, CUPRAC, and DPPH), antimicrobial (3 Gram (-), 4/6 Gram (+), one tuberculosis and one fungus), and enzyme inhibition (acetylcholinesterase, butyrylcholine esterase, tyrosinase, α-amylase, and α- glucosidase) for the all synthesized compounds (1-25) were evaluated. And also, four most active compounds (4, 12, 18a+b, and 25) from each group were evaluated to the human cervical cancer cell line (HeLa) and anticancer screening tests against the human retinal normal cell line (RPE). Compound 4 showed HeLa and RPE cancer cell activities as much as cisplatin. The synthesized compounds were characterized by spectroscopic methods (NMR, FT-IR, UV, LC-QTOF-MS) and the ACD NMR program's help.
DOI
10.3906/kim-2012-25
Keywords
Hydroxy benzoin/benzil, benzoin/benzil-O-β-D-glucoside, antioxidant, antimicrobial, enzyme inhibition, cytotoxic activity
First Page
788
Last Page
804
Recommended Citation
YAYLI, N, KILIÇ, G, ÇELİK, G, KAHRİMAN, N, KANBOLAT, Ş, BOZDEVECİ, A, KARAOĞLU, Ş. A, ALİYAZICIOĞLU, R, SELLİTEPE, H. E, DOĞAN, İ. S, & AYDIN, A (2021). Synthesis of hydroxy benzoin/benzil analogs and investigation of their antioxidant,antimicrobial, enzyme inhibition, and cytotoxic activities. Turkish Journal of Chemistry 45 (3): 788-804. https://doi.org/10.3906/kim-2012-25
