Synthesis and molecular docking study of novel COVID-19 inhibitors

Authors

ZUHAL GERÇEK
DENİZ CEYHAN
EROL ERÇAĞ

DOI

10.3906/kim-2012-55

Abstract

In 2020, the world tried to combat the corona virus (COVID-19) pandemic. A proven treatment method specific to Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is still not found. In this study, seven new antiviral compounds were designed for COVID-19 treatment. The ability of these compounds to inhibit COVID-19's RNA processing was calculated by the molecular docking study. It has been observed that the compounds can have high binding affinities especially against NSP12 (between -9.06 and -8.00 kcal/mol). The molecular dynamics simulation of NSP12-ZG 7 complex proved the stability of interaction. The synthesis of two most active molecules was performed by one-pot reaction and characterized by FT-IR, 1H-NMR, 13C-NMR, and mass spectroscopy. The compounds presented with their synthesis are inhibitory core structures against SARS-CoV-2 infection.

Keywords

COVID-19, SARS-CoV-2, molecular docking study, antiviral drug

First Page

704

Last Page

718

Recommended Citation

GERÇEK, ZUHAL; CEYHAN, DENİZ; and ERÇAĞ, EROL (2021) "Synthesis and molecular docking study of novel COVID-19 inhibitors," Turkish Journal of Chemistry: Vol. 45: No. 3, Article 17. https://doi.org/10.3906/kim-2012-55
Available at: https://journals.tubitak.gov.tr/chem/vol45/iss3/17