Synthesis, characterization, and biological evaluation of new copper complexes ofnaphthyl pyrazole ligands

Authors

MELEK HINIS
KULDIP SINGH
DEMET ERDÖNMEZ
AYFER MENTEŞ

DOI

10.3906/kim-2010-5

Abstract

Two naphthalene pyrazole ligands were synthesized using KOH/DMSO and Cu catalyst and characterized with FT-IR, ESIMS, 1H, and 13C NMR spectroscopies. The crystal structures of 1-(2-methylnaphthalen-1-yl)-1H-pyrazole (MeNap-Pz) ligand have been determined with X-ray crystal structure analysis. Reaction of the ligands with Cu(NO3)2x3.5H2O gave two new complexes and characterized with magnetic susceptibility, molar conductance, FT-IR, LCMS-MS, ICP-OES, NMR, thermogravimetric analysis, and ESR spectra. The spectral data of the ligands are coordinated to the metal ion through the nitrogen atoms of the pyrazole ring. Consequently, it has been determined that [Cu(MeNap-Pz)2 (NO3)]NO3.2H2O complex showed square planar geometry and [Cu(NapMe-Pz)2(NO3)2].H2O complex showed octahedral geometry. All compounds were screened for in vitro antibacterial activity and copper complexes have been shown to be effective on bacteria.

Keywords

Naphthyl, pyrazole, copper, antimicrobial activity

First Page

634

Last Page

646

Recommended Citation

HINIS, MELEK; SINGH, KULDIP; ERDÖNMEZ, DEMET; and MENTEŞ, AYFER (2021) "Synthesis, characterization, and biological evaluation of new copper complexes ofnaphthyl pyrazole ligands," Turkish Journal of Chemistry: Vol. 45: No. 3, Article 11. https://doi.org/10.3906/kim-2010-5
Available at: https://journals.tubitak.gov.tr/chem/vol45/iss3/11