Turkish Journal of Chemistry
Abstract
A series of novel imidazo[1,2-a]pyrimidine containing tri/tetrasubstituted imidazole derivatives (1-10) has been synthesized via sequential two-step, one-pot, multicomponent reaction using imidazo[1,2-a]pyrimidine-2-carbaldehyde, benzil, primary amines, and ammonium acetate catalyzed by p-toluenesulfonic acid under microwave-assisted conditions. The results showed that target compounds can be obtained from a wide range of primary amines bearing different functional groups with moderate to good yields (46%-80%) under optimum reaction conditions. This method provides a green protocol for imidazo[1,2-a]pyrimidine containing tri/ tetrasubstituted imidazole derivatives due to ethyl alcohol as a green solvent, microwave irradiation as a greener heating method and one-pot multicomponent reaction as a green technique. The synthesized compounds have been elucidated using various spectroscopic tools such as FT-IR, 1H NMR, 13C NMR, and MS.
DOI
10.3906/kim-2009-40
Keywords
Imidazo[1, 2-a]pyrimidine, tri/tetrasubstituted imidazole, microwave synthesis, sequential, one-pot reaction, p-toluenesulfonic acid
First Page
219
Last Page
230
Recommended Citation
GÜNGÖR, TUĞBA
(2021)
"Microwave assisted, sequential two-step, one-pot synthesis of novel imidazo[1,2-a]pyrimidine containing tri/tetrasubstituted imidazole derivatives,"
Turkish Journal of Chemistry: Vol. 45:
No.
1, Article 22.
https://doi.org/10.3906/kim-2009-40
Available at:
https://journals.tubitak.gov.tr/chem/vol45/iss1/22
