Cytotoxic and apoptotic potential of some coumarin and 2-amino-3-carbonitrile selenophene derivatives in prostate cancer

Authors

METİN YILDIRIM
MEHMET ERŞATIR
BADEL ARSLAN
ELİFE SULTAN GİRAY

DOI

10.3906/kim-2008-56

Abstract

3-acetyl coumarin derivatives (1a-d) are formed as a result of condensation of salicylaldehyde derivatives and ethyl acetoacetate and were converted into coumarin-selenophene hybrid compounds (2a-d) in the basic medium by modified Gewald reaction in the presence of malononitrile and selenium. Products are characterized by nuclear magnetic resonance (NMR). The prepared compounds are screened for their anticancer activity against DU-145 cell line. In addition, selected target compounds are evaluated for apoptosis and oxidative stress on DU-145 (prostate carcinoma) cell lines.

Keywords

Coumarin, selenophene, antitumor agents, antioxidant activity, heterocycles

First Page

192

Last Page

198

Recommended Citation

YILDIRIM, METİN; ERŞATIR, MEHMET; ARSLAN, BADEL; and GİRAY, ELİFE SULTAN (2021) "Cytotoxic and apoptotic potential of some coumarin and 2-amino-3-carbonitrile selenophene derivatives in prostate cancer," Turkish Journal of Chemistry: Vol. 45: No. 1, Article 19. https://doi.org/10.3906/kim-2008-56
Available at: https://journals.tubitak.gov.tr/chem/vol45/iss1/19