Fabrication and characterization of boric acid-crosslinked ethyl cellulose and polyvinyl alcohol films as potential drug release systems for topical drug delivery

Authors

NASRIN ALIASGHARLOU
FARZIN ASGHARI SANA
SABA KHOSHBAKHT
PEZHMAN ZOLFAGHARI
HAMED CHARKHIAN

DOI

10.3906/kim-2008-23

Abstract

In this study, boric acid (BA) is employed as a crosslinking agent to improve the characteristics of two commonly used polymeric films, ethyl cellulose (EC) and polyvinyl alcohol (PVA), for topical drug delivery applications. The developed films are characterized by FTIR spectroscopy and SEM analysis. The results show that the surfaces of the prepared films are even and transparent, except for the BA-modified EC sample. The initial cumulative release for erythromycin (EM) is found to be 0.30 and 0.36 mg/mL for EC and PVA films, which drops to 0.25 and 0.20 mg/mL after BA crosslinking, respectively, after 1 h at 25 °C. Further, the developed formulations are stable for 75 days. Also, the antibacterial activity of the developed formulations is investigated against S. aureus (ATCC® 25923TM and ATCC® 29213TM). The obtained data confirm that the application of BA as the crosslinking agent extends the release of EM from EC and PVA polymeric films. The findings of this study suggest that BA-crosslinked EC and PVA films are promising carriers for controlled topical drug delivery applications.

Keywords

Drug delivery system, polymeric film, polyvinyl alcohol, ethyl cellulose, boric acid, erythromycin

First Page

1723

Last Page

1732

Recommended Citation

ALIASGHARLOU, NASRIN; SANA, FARZIN ASGHARI; KHOSHBAKHT, SABA; ZOLFAGHARI, PEZHMAN; and CHARKHIAN, HAMED (2020) "Fabrication and characterization of boric acid-crosslinked ethyl cellulose and polyvinyl alcohol films as potential drug release systems for topical drug delivery," Turkish Journal of Chemistry: Vol. 44: No. 6, Article 24. https://doi.org/10.3906/kim-2008-23
Available at: https://journals.tubitak.gov.tr/chem/vol44/iss6/24