[n.3.0]Bicycles (n = 3-6) can be synthesized using palladium-catalyzed asymmetric allylic alkylation followed by rutheniumcatalyzed cycloisomerization. New types of triarylphosphino-1,2-diaminooxazoline ligands show the same high levels of enantioselectivity observed with Trost ligand when employed in Pd-catalyzed allylic alkylation reactions. The enyne products of these allylic alkylation reactions were further elaborated using a Ru-catalyzed redox isomerization process, for which a mechanism is proposed.
Synthetic method development, asymmetric catalysis, Tsuji-Trost-reaction, palladium-catalyzed asymmetric allylic alkylation, ruthenium-catalyzed cycloisomerization
"Effective synthesis of bicyclodienes via palladium-catalyzed asymmetric allylic alkylationand ruthenium-catalyzed cycloisomerization,"
Turkish Journal of Chemistry: Vol. 44:
6, Article 1.
Available at: https://journals.tubitak.gov.tr/chem/vol44/iss6/1