Turkish Journal of Chemistry
DOI
10.3906/kim-2006-22
Abstract
A series of Schiff bases have been successfully synthesized through the acid-catalyzed condensation of S-substituted dithiocarbazates and three enantiomerically pure monoterpenes, (1R)-(+)-camphor, (1S)-(-)-camphor, (1R)-(-)-camphorquinone, (1S)- (+)-camphorquinone, (R)-(-)-carvone and (S)-(+)-carvone. Spectroscopic results revealed that the Schiff bases containing camphor or carvone likely adopted an E-configuration along the characteristic imine bond while those containing camphorquinone assumed a Z-configuration. The antidengue potential of these compounds was evaluated based on DENV 2 caused cytopathic effect (CPE) reduction-based in vitro evaluation. The compounds were validated through secondary foci forming unit reduction assay (FFURA). Compounds were also tested for their cytotoxicity against Vero cells. The compounds showed variable degrees of antiviral activity with the camphor compounds displaying the highest antidengue potential. The enantiomers of the compounds behaved almost similarly during the antiviral evaluation.
Keywords
Dithiocarbazate Schiff base, enantiomers, camphor, camphorquinone, carvone, antidengue
First Page
1395
Last Page
1409
Recommended Citation
MARYAM, MAQSOOD; TAN, SANG LOON; CROUSE, KAREN ANN; TAHIR, MOHAMED IBRAHIM MOHAMED; and CHEE, HUI YEE
(2020)
"Synthesis, characterization and evaluation of antidengue activity of enantiomeric Schiffbases derived from S-substituted dithiocarbazate,"
Turkish Journal of Chemistry: Vol. 44:
No.
5, Article 15.
https://doi.org/10.3906/kim-2006-22
Available at:
https://journals.tubitak.gov.tr/chem/vol44/iss5/15
