Turkish Journal of Chemistry
DOI
10.3906/kim-2002-76
Abstract
Schiff-base-bearing new bis(thiosemicarbazone) derivatives were prepared from terephthalaldehyde and various thiosemicarbazides. FT--IR,$^{\, 1}$H NMR, $^{13}$C NMR, and UV--Vis spectroscopic methods and elemental analysis were used to elucidate the identification of the synthesized molecules. The in vitro antioxidant activity of the synthesized compounds was analysed with the 1,1-diphenyl-2-picryl hydrazyl free-radical-trapping process. The synthesized compounds exhibited lower antioxidant activity than the standard ascorbic acid. IC$_{50}$ values of the synthesized molecules measured from 3.81 $\pm $ 0.01 to 29.05 $\pm $ 0.11 $\mu$M. Among the synthesized compounds, compound 3 had the best antioxidant activity. Moreover, this study explained the structure--activity relationship of the synthesized molecules with different substituents in radical trapping reactions.
Keywords
Thiosemicarbazides, Schiff bases, DPPH, structure-activity relationship, spectroscopic methods
First Page
1085
Last Page
1099
Recommended Citation
YAKAN, HASAN
(2020)
"Preparation, structure elucidation, and antioxidant activity of new bis(thiosemicarbazone) derivatives,"
Turkish Journal of Chemistry: Vol. 44:
No.
4, Article 16.
https://doi.org/10.3906/kim-2002-76
Available at:
https://journals.tubitak.gov.tr/chem/vol44/iss4/16
