Design of an amphiphilic hyperbranched core/shell-type polymeric nanocarrier platform for drug delivery

Authors

AYÇA BAL ÖZTÜRK
NESRİN OĞUZ
HANDE TEKARSLAN ŞAHİN
SERKAN EMİK
EMİNE ALARÇİN

Abstract

An amphiphilic core/shell-type polymer-based drug carrier system (HPAE- PCL-b-MPEG), composed of hyperbranched poly(aminoester)-based polymer (HPAE) as the core building block and poly(ethylene glycol)-bpoly(ε-caprolactone) diblock polymers (MPEG-b-PCL) as the shell building block, was designed. The synthesized polymers were characterized with FTIR, $^{1}$H NMR, $^{13}$C NMR, and GPC analysis. Monodisperse HPAE-PCL-bMPEG nanoparticles with dimensions of

DOI

10.3906/kim-1910-35

Keywords

Hyperbranched polymer, poly(aminoester), nanoparticle, drug delivery, 5-fluorouracil

First Page

518

Last Page

534

Recommended Citation

ÖZTÜRK, AYÇA BAL; OĞUZ, NESRİN; ŞAHİN, HANDE TEKARSLAN; EMİK, SERKAN; and ALARÇİN, EMİNE (2020) "Design of an amphiphilic hyperbranched core/shell-type polymeric nanocarrier platform for drug delivery," Turkish Journal of Chemistry: Vol. 44: No. 2, Article 19. https://doi.org/10.3906/kim-1910-35
Available at: https://journals.tubitak.gov.tr/chem/vol44/iss2/19