Selective modifications at the different positions of cyclodextrins: a review of strategies

Authors

JIA YUE LIU
XIAO ZHANG
BINGREN TIAN

DOI

10.3906/kim-1910-43

Abstract

Cyclodextrins (CDs) are natural, nontoxic, and biodegradable macrocyclic oligosaccharides. As supramolecular hosts, CDs have numerous applications in many aspects. However, nonsubstituted CDs have the disadvantages of solubility, unspecific recognition sites, and weak interactions with guest molecules. Therefore, new CD-based derivatives are successfully designed, synthesized, and widely used in various fields. This contribution outlines the research progress in CD derivatives. In particular, this review emphasizes the synthesis and application of CDs modified through functionalization in definite positions, random substitution, and reconstruction of the skeleton. At the end of this review, a summary and future directions are presented.

Keywords

Cyclodextrin, modification, synthesis, application

First Page

261

Last Page

278

Recommended Citation

LIU, JIA YUE; ZHANG, XIAO; and TIAN, BINGREN (2020) "Selective modifications at the different positions of cyclodextrins: a review of strategies," Turkish Journal of Chemistry: Vol. 44: No. 2, Article 1. https://doi.org/10.3906/kim-1910-43
Available at: https://journals.tubitak.gov.tr/chem/vol44/iss2/1