Choline derivatives immobilized on silica to catalyze transesterification reaction for production of glycerophosphocholine

Authors

LONGHUI WEI
BINGLIN LI
XIAOLI ZHANG
KAI TANG
WENWEN ZHENG
DAN CHEN
BINXIA ZHAO

DOI

10.3906/kim-1907-43

Abstract

Choline derivatives were covalently immobilized on the surface of γ -aminated silica. The obtained immobilized choline derivative was then successfully used for a transesterification reaction to produce glycerophosphocholine (GPC). Fourier transform infrared analysis and thermogravimetric analysis/differential thermal gravimetry indicated that the surface of the γ -aminated silica was covered by choline derivatives and the highest immobilization amount reached 1.1 mmol/g under optimal conditions. More importantly, the highest yield of GPC reached 97.9% during transesterification. With regard to GPC in food or medicine for human use, the immobilization technology can avoid catalyst contamination of the product and increase the safety of the product. The recyclability and stability of the immobilized choline derivative were excellent, as demonstrated by its use 20 times without any loss of productivity. A first-order kinetic model was employed and the relevant parameters were calculated to investigate kinetic characteristics of transesterification.

Keywords

Choline derivatives, glycerophosphocholine, transesterification reaction, immobilized choline derivative, kinetic

First Page

249

Last Page

260

Recommended Citation

WEI, LONGHUI; LI, BINGLIN; ZHANG, XIAOLI; TANG, KAI; ZHENG, WENWEN; CHEN, DAN; and ZHAO, BINXIA (2020) "Choline derivatives immobilized on silica to catalyze transesterification reaction for production of glycerophosphocholine," Turkish Journal of Chemistry: Vol. 44: No. 1, Article 19. https://doi.org/10.3906/kim-1907-43
Available at: https://journals.tubitak.gov.tr/chem/vol44/iss1/19