Turkish Journal of Chemistry
Abstract
New bis(isatins-thio/carbohydrazones) based on Schiff bases were prepared from terephthalaldehyde biscarbohydrazone and 5-substituted isatins in the presence of a drop of sulfuric acid under reflux in ethanol. Terephthalaldehyde bis(thio/carbohydrazone) was synthesized by the reaction of (thio)/carbohydrazide and terephthalaldehyde in the presence of a few drops of acetic acid under reflux in ethanol. The structures of these synthesized compounds were determined using IR, $^{1}$H NMR, and $^{13}$C NMR spectroscopy and elemental analysis. The in vitro antioxidant activity of all the compounds was determined by the 1,1-diphenyl-2-picryl hydrazyl (DPPH.) free radical scavenging method. Compound 2 showed the best antioxidant activity.
DOI
10.3906/kim-1910-13
Keywords
Isatin, carbohydrazone, Schiff bases, DPPH, spectroscopic techniques
First Page
237
Last Page
248
Recommended Citation
MUĞLU, HALİT; YAKAN, HASAN; and BAKIR, TEMEL KAN
(2020)
"Synthesis, spectroscopic studies, and antioxidant activities of novelthio/carbohydrazones and bis-isatin derivatives from terephthalaldehyde,"
Turkish Journal of Chemistry: Vol. 44:
No.
1, Article 18.
https://doi.org/10.3906/kim-1910-13
Available at:
https://journals.tubitak.gov.tr/chem/vol44/iss1/18
