Entrapment of organic fluorophores in calcium phosphate nanoparticles withslow release

Authors

LAILA SADALLAH
AICHA BOUKHRISS
HASSAN HANNACHE
SAID GMOUH

DOI

10.3906/kim-1902-57

Abstract

Two organic fluorophores, fluorescein (F) and rhodamine B (Rd), were entrapped in calcium phosphate nanoparticles. The as-obtained nanoparticles can be used for biological release applications. For this aim, calcium phosphate nanoparticles were synthesized using the precipitation method. Structural analysis of these nanoparticles was performed using XRD, FTIR, and Raman spectroscopy, confirming that the synthesized nanoparticles were hydroxyapatite. TEM and SEM analyses demonstrated that these nanoparticles had a size of 20 nm and a well-defined morphology. F and Rd (about 0.5 wt.%) were entrapped in these nanoparticles and their release, as a function of time, was studied via UV-Vis spectroscopy. The obtained results showed that the release of both fluorophores was progressive over time. The trapping efficiencies of the fluorophores were 67.15% and 90.76% for F and Rd, respectively.

Keywords

Calcium phosphate nanoparticles, slow release, entrapment, organic fluorophores

First Page

142

Last Page

154

Recommended Citation

SADALLAH, LAILA; BOUKHRISS, AICHA; HANNACHE, HASSAN; and GMOUH, SAID (2020) "Entrapment of organic fluorophores in calcium phosphate nanoparticles withslow release," Turkish Journal of Chemistry: Vol. 44: No. 1, Article 11. https://doi.org/10.3906/kim-1902-57
Available at: https://journals.tubitak.gov.tr/chem/vol44/iss1/11