Synthesis of SMZ derivatives and investigation of effects on germination, root, and plant growth of \textit{Arabidopsis thaliana} L.

Authors

TUĞBA GÜNGÖR
FERAH CÖMERT ÖNDER
FATİH SEZER
ASLIHAN ÖZBİLEN
KEMAL MELİH TAŞKIN
MEHMET AY

DOI

10.3906/kim-1901-27

Abstract

A series of sulfonamide derivatives were synthesized by reactions with various functional groups containing benzenesulfonyl chlorides and aniline derivatives under different substitution reaction conditions. The structures of SMZ derivatives were confirmed with melting point, FT-IR, $^{1}$H NMR, $^{13}$C NMR, and LC-MS/MS techniques. In order to investigate the cytotoxic effects of these derivatives, we used a model plant species. The synthesized compounds (S1-S5) and sulfamethazine (SMZ) as a positive control were applied to Arabidopsis thaliana seeds. Our results indicated that S3 and S4 induced shorter roots and lower wet weight in plants. Plants treated with S2 and S5 showed no growth effects, similar to the untreated control group, while S1 slightly reduced root length and wet weight. These results suggest that S3 and the newly synthesized S4 derivatives have potential for use as herbicides since they possess cytotoxic effects on A. thaliana plants.

Keywords

SMZ derivatives, Arabidopsis thaliana L., herbicide, sulfonamide, synthesis

First Page

1123

Last Page

1133

Recommended Citation

GÜNGÖR, TUĞBA; ÖNDER, FERAH CÖMERT; SEZER, FATİH; ÖZBİLEN, ASLIHAN; TAŞKIN, KEMAL MELİH; and AY, MEHMET (2019) "Synthesis of SMZ derivatives and investigation of effects on germination, root, and plant growth of \textit{Arabidopsis thaliana} L.," Turkish Journal of Chemistry: Vol. 43: No. 4, Article 12. https://doi.org/10.3906/kim-1901-27
Available at: https://journals.tubitak.gov.tr/chem/vol43/iss4/12