Boric acid as an efficient and green catalyst for the synthesis of 2-amino-4,6-diarylnicotinonitrile under microwave irradiation in solvent-free conditions

Authors

ZAHRA HOSSEINZADEH
ALI RAMAZANI
NIMA RAZZAGHI-ASL
KATARZYNA SLEPOKURA
TADEUSZ LIS

Abstract

Microwave irradiation has been used to improve the one-pot synthesis of substituted 2-amino-4,6-diarylnicoti- nonitrile in the presence of boric acid as an efficient and green catalyst under solvent-free conditions within 48--60 s. All the analogs that have not been reported previously were characterized by their melting points, IR, $^{1}$H NMR, and $^{13}$C NMR spectra. One of the structures was verified by the analysis of a single crystal. The reported synthetic procedure provided remarkable advantages such as short reaction times, excellent yield, facile workup, and the use of a green catalyst.

DOI

10.3906/kim-1807-101

Keywords

Boric acid, microwave irradiation, solvent-free, green method, 2-amino-4, 6-diarylnicotinonitrile

First Page

464

Last Page

474

Recommended Citation

HOSSEINZADEH, Z, RAMAZANI, A, RAZZAGHI-ASL, N, SLEPOKURA, K, & LIS, T (2019). Boric acid as an efficient and green catalyst for the synthesis of 2-amino-4,6-diarylnicotinonitrile under microwave irradiation in solvent-free conditions. Turkish Journal of Chemistry 43 (2): 464-474. https://doi.org/10.3906/kim-1807-101