The protective effect of N-acetylcysteine amide against paraquat-induced neurotoxicity

Authors

BURHAN ATEŞ
NİGAR VARDI
HAKAN PARLAKPINAR
MERVE GÖKŞİN KARAASLAN
İSMET YILMAZ
NURAN ERCAL

DOI

10.3906/kim-1706-8

Abstract

N-acetylcysteine amide (NACA) is a new antioxidant molecule with powerful radical scavenging properties. The aim of this study was to investigate neuroprotective effects of NACA against paraquat (PQ) toxicity in the midbrains of rats by using motor coordination tests and biochemical and histological analysis. Thirty adult Wistar albino rats were divided into three groups: Group 1: control (n = 10), Group 2: PQ (10 mg/kg) (n = 10), and Group 3: PQ (10 mg/kg) $+$ NACA (100 mg/kg) (n = 10). NACA was administrated intraperitoneally 30 min before PQ injection. Performance was measured for a period of 28 days. The rotarod and accelerod tests were performed prior to and after the experimental period. After the experimental period, rats were sacrificed and midbrain tissues were removed. According to biochemical data, malondialdehyde levels exhibited a significant increase (P $

Keywords

Thiol antioxidant, N-acetylcysteine amide, paraquat, neuroprotective, glutathione

First Page

39

Last Page

49

Recommended Citation

ATEŞ, BURHAN; VARDI, NİGAR; PARLAKPINAR, HAKAN; KARAASLAN, MERVE GÖKŞİN; YILMAZ, İSMET; and ERCAL, NURAN (2019) "The protective effect of N-acetylcysteine amide against paraquat-induced neurotoxicity," Turkish Journal of Chemistry: Vol. 43: No. 1, Article 3. https://doi.org/10.3906/kim-1706-8
Available at: https://journals.tubitak.gov.tr/chem/vol43/iss1/3