Quaternary ammonium salts are a group of compounds with diverse biological properties, the most important of which are their antiviral, antibacterial, and antifungal activities. The quaternization reactions of 5'-$O$-tosyl derivatives of uridine and thymidine with triethylamine, trimethylamine, 4-($N$,$N$-dimethylamino)pyridine, 2-methylpyridine, and pyridine are described in this article. Two of the synthesized compounds are exceptional because they are first of this type that demonstrate concentration-dependent antifungal in vitro activity against two species of the genus Candida in minimal YNB-SG medium. The experimental results have been extended by adding full atom molecular dynamics simulations and substrates and products energies evaluation.
Quaternary ammonium salts, uridine-5\textquotesingle-ammonium derivatives, thymidine-5\textquotesingle-ammonium derivatives
DMOCHOWSKA, BARBARA; PELLOWSKA-JANUSZEK, LUCYNA; SAMASZKO-FIERTEK, JUSTYNA; SLUSARZ, RAFAL; WAKIEC, ROLAND; and MADAJ, JANUSZ
"Efficient synthesis and antifungal investigation of nucleosides' quaternary ammonium salt derivatives,"
Turkish Journal of Chemistry: Vol. 43:
1, Article 14.
Available at: https://journals.tubitak.gov.tr/chem/vol43/iss1/14