Synthesis of acetamide derivatives of 1,2,4-triazole bearing azinane and their binding interactions with bovine serum albumin using spectroscopic techniques

Authors

JAVED IQBAL
AZIZ UR REHMAN
MUHAMMAD ATHAR ABBASI
SABAHAT ZAHRA SIDDIQUI
HIRA KHALID
SABINA JHAUMEER LAULLOO
NAUSHEEN JOONDAN
ANIISAH BANU TAUPASS
SHAHID RASOOL
SYED ADNAN ALI SHAH

Abstract

A new series of acetamide derivatives containing 1,2,4-triazole and azinane moieties has been synthesized and characterized using $^{1}$H NMR, $^{13}$C NMR, IR, and EI-MS spectroscopic analysis. The intermediate triazole was synthesized through a sequential synthesis of carboxylate and carbohydrazide. The bovine serum albumin (BSA) binding of the newly synthesized 1,2,4-triazole derivatives was evaluated along with thermodynamics, site-selective binding, and synchronous study. The results obtained by BSA binding as well as thermodynamic studies justify that all the compounds show spontaneous interaction with BSA and could be effectively distributed and eliminated from the body. Therefore, the triazole-based analogs might be a useful strategy for designing new drug systems.

DOI

10.3906/kim-1801-95

Keywords

Acetamides, 1, 2, 4-triazole, azinane, sulfonamide, bovine serum albumin binding

First Page

1459

Last Page

1478

Recommended Citation

IQBAL, JAVED; REHMAN, AZIZ UR; ABBASI, MUHAMMAD ATHAR; SIDDIQUI, SABAHAT ZAHRA; KHALID, HIRA; LAULLOO, SABINA JHAUMEER; JOONDAN, NAUSHEEN; TAUPASS, ANIISAH BANU; RASOOL, SHAHID; and SHAH, SYED ADNAN ALI (2018) "Synthesis of acetamide derivatives of 1,2,4-triazole bearing azinane and their binding interactions with bovine serum albumin using spectroscopic techniques," Turkish Journal of Chemistry: Vol. 42: No. 6, Article 2. https://doi.org/10.3906/kim-1801-95
Available at: https://journals.tubitak.gov.tr/chem/vol42/iss6/2