An efficient water-mediated synthetic route for the alkylation of heteroarenes

Authors

PINAR SEYİTDANLIOĞLU
ESSAM HAMIED AHMED HANASHALHALSHAHABY
CANAN ÜNALEROĞLU

DOI

10.3906/kim-1802-18

Abstract

An efficient synthetic route has been described for the alkylation of 1$H$-indole, 1$H$-benzimidazole, and 1$H$-benzotriazole. This approach features the alkylation of heteroaromatics through in situ generated enones from ketonic Mannich bases under metal-free conditions. A series of alkylated heteroaromatics have been synthesized via the K10 catalyzed alkylation reactions of these heteroaromatics with a variety of ketonic Mannich bases. Environmentally benign K10 catalyst, water-mediated mild reaction conditions, and the efficient synthesis of alkylated products are the advantages of this alkylation method.

Keywords

Mannich base, alkylation reaction of 1$H$-indole 1$H$-benzimidazole and 1$H$-benzotriazole, K10, environmentally friendly synthesis

First Page

1598

Last Page

1610

Recommended Citation

SEYİTDANLIOĞLU, PINAR; HANASHALHALSHAHABY, ESSAM HAMIED AHMED; and ÜNALEROĞLU, CANAN (2018) "An efficient water-mediated synthetic route for the alkylation of heteroarenes," Turkish Journal of Chemistry: Vol. 42: No. 6, Article 11. https://doi.org/10.3906/kim-1802-18
Available at: https://journals.tubitak.gov.tr/chem/vol42/iss6/11