Recent synthetic methodologies for pyrimidine and its derivatives

Authors

FARHAT IBRAHEEM
FURQAN AHMAD SADDIQUE
SANA ASLAM
ASIM MANSHA
TAHIR FAROOQ
MATLOOB AHMAD

DOI

10.3906/kim-1806-8

Abstract

Pyrimidine derivatives are well known due to their remarkable pharmacological potential in various fields of science, and they are also present in some natural substances like DNA and RNA. These scaffolds manifest diversified biological activities such as antimicrobial, antiinflammatory, anti-HIV, antitubercular, antitumor, antineoplastic, and antimalarial. A pyrimidine ring is constructed when chalcones, amidines, guanidine, nitriles, isocyanates, urea, thiourea, and aminopyrazoles undergo condensation, coupling, or cyclization reactions. In this context, the present review illustrates a variety of novel and efficient synthetic approaches towards the synthesis of pyrimidine and its derivatives that were reported recently.

Keywords

Pyrimidine, synthesis, multicomponent, chalcones, guanidine, urea, thiourea

First Page

1421

Last Page

1458

Recommended Citation

IBRAHEEM, FARHAT; SADDIQUE, FURQAN AHMAD; ASLAM, SANA; MANSHA, ASIM; FAROOQ, TAHIR; and AHMAD, MATLOOB (2018) "Recent synthetic methodologies for pyrimidine and its derivatives," Turkish Journal of Chemistry: Vol. 42: No. 6, Article 1. https://doi.org/10.3906/kim-1806-8
Available at: https://journals.tubitak.gov.tr/chem/vol42/iss6/1