Turkish Journal of Chemistry
DOI
10.3906/kim-1710-20
Abstract
The synthesis and characterisation including $^{1}$H and $^{13}$C NMR spectroscopy of a Mannich~base~1,4-di-(5-acetamido-2-hydroxybenzyl)piperazine~is herein reported. The Mannich reaction leading to the formation of the ligand took place at both ends of piperazine. Four metal complexes [Cu(II) and Fe(III)] including those bearing thiocyanate groups (SCN-) in N- and S-bonding modes have been studied for their abilities to mimic catecholase oxidase. All the metal complexes are catalytically active with the highest turnover rate (k$_{cat})$ recorded for complex 3. The catalytic process as monitored by $^{1}$H NMR spectroscopy (isolation of 3, 5-DTBQ) and iodometric titration revealed the formation of H$_{2}$O$_{2}$ and thus implied that the mechanism of oxidation is through the formation of a semiquinolate species.
First Page
1275
Last Page
1284
Recommended Citation
AYENI, AYOWOLE OLAOLU and WATKINS, GARETH MOSTYN
(2018)
"Synthesis and evaluation of catecholase activities of metal complexes of 1,4-substituted piperazine Mannich base of 4-acetamidopheno,"
Turkish Journal of Chemistry: Vol. 42:
No.
5, Article 7.
https://doi.org/10.3906/kim-1710-20
Available at:
https://journals.tubitak.gov.tr/chem/vol42/iss5/7
