Turkish Journal of Chemistry
Abstract
2-Substituted 8-propargyloxyquinoline derivatives have been synthesized from 2-substituted-8-hydroxyquinolines by O-propargylation method (30%-98% yields). The newly synthesized compounds were tested for in vitro antioxidant activities such as DPPH radical scavenging, ferrous chelating, and reducing power activities. The maximum radical scavenging (46.5%) and reducing power activities were obtained from 1 and maximum ferrous chelating effect was obtained from 6 (72.1%) at the concentration of 500 $\mu $g/mL. To indicate DNA binding activity of the complexes calf thymus DNA was used. The compounds were also evaluated for their antimicrobial activity against three gram-positive and three gram-negative bacteria. Compounds 3 and 5 exhibited antibacterial activity against all tested gram-positive bacteria.
DOI
10.3906/kim-1805-77
Keywords
Quinoline, propargyloxyquinoline, antioxidant, antibacterial, DNA binding activity
First Page
1358
Last Page
1369
Recommended Citation
GÜMÜŞ, AYŞEGÜL; OKUMUŞ, VEYSİ; and GÜMÜŞ, SELÇUK
(2018)
"Synthesis of 2-substituted 8-propargyloxyquinoline derivatives and determination of their antioxidant, antibacterial, and DNA binding activities,"
Turkish Journal of Chemistry: Vol. 42:
No.
5, Article 14.
https://doi.org/10.3906/kim-1805-77
Available at:
https://journals.tubitak.gov.tr/chem/vol42/iss5/14
