One-pot synthesis of novel quinoline- and quinolone-substituted 1,2,3-triazoles has been performed from the key intermediates, quinoline- and quinolone-substituted propargyl derivatives 1-3 (48%-88% yields). The antioxidant properties of the newly synthesized compounds, 1a-1c, 2a-2c, and 3a-3c, were evaluated by monitoring DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging abilities, metal chelating effects, and reducing power. The scavenging effects of compounds on the free radical decreased in the order of 3b$>$ 3a$>$ 1b} and were found to be 36.3%, 34.9%, and 27.6% at the concentration of 500 $\mu $g/mL, respectively. All of the compounds showed low chelating capacity. Furthermore, the antibacterial activity was studied against gram-positive and gram-negative bacteria and the DNA binding ability of the compounds was evaluated with calf thymus DNA using agarose gel electrophoresis.
GÜMÜŞ, AYŞEGÜL and OKUMUŞ, VEYSİ
"Synthesis and biological evaluation of quinoline-triazole and quinolone-triazole conjugates,"
Turkish Journal of Chemistry: Vol. 42:
5, Article 13.
Available at: https://journals.tubitak.gov.tr/chem/vol42/iss5/13