Turkish Journal of Chemistry
Abstract
We report herein the synthesis, characterization, and cytotoxicity evaluations of some newer oxadiazole and triazole analogues (5a-j). The cytotoxicity of all the title compounds were evaluated as per the National Cancer Institute protocol in a one-dose assay (10 $\mu $M) on nine different panels of 59 cancer cell lines. 2-$\{$5-[(2,4-Dichlorophenoxy)methyl]-1,3,4-oxadiazol-2-yl$\}$phenol (5e) showed the maximum cytotoxicity among the series of ten compounds. The cytotoxicity of 5e was comparable to that of the standard anticancer drug, 5-fluorouracil, and better than that of imatinib. The structure activity relationship was also discussed.
DOI
10.3906/kim-1803-25
Keywords
Anticancer activity, cancer cell lines, cytotoxicity, one dose assay, oxadiazole, triazole
First Page
1334
Last Page
1343
Recommended Citation
AHSAN, M. J (2018). Synthesis and cytotoxicity evaluation of [(2,4-dichlorophenoxy)methyl]-5-aryl-1,3,4-oxadiazole/4$H$-1,2,4-triazole analogues. Turkish Journal of Chemistry 42 (5): 1334-1343. https://doi.org/10.3906/kim-1803-25
