Synthesis and cytotoxicity evaluation of [(2,4-dichlorophenoxy)methyl]-5-aryl-1,3,4-oxadiazole/4$H$-1,2,4-triazole analogues

Authors

MOHAMED JAWED AHSAN

Abstract

We report herein the synthesis, characterization, and cytotoxicity evaluations of some newer oxadiazole and triazole analogues (5a-j). The cytotoxicity of all the title compounds were evaluated as per the National Cancer Institute protocol in a one-dose assay (10 $\mu $M) on nine different panels of 59 cancer cell lines. 2-$\{$5-[(2,4-Dichlorophenoxy)methyl]-1,3,4-oxadiazol-2-yl$\}$phenol (5e) showed the maximum cytotoxicity among the series of ten compounds. The cytotoxicity of 5e was comparable to that of the standard anticancer drug, 5-fluorouracil, and better than that of imatinib. The structure activity relationship was also discussed.

DOI

10.3906/kim-1803-25

Keywords

Anticancer activity, cancer cell lines, cytotoxicity, one dose assay, oxadiazole, triazole

First Page

1334

Last Page

1343

Recommended Citation

AHSAN, MOHAMED JAWED (2018) "Synthesis and cytotoxicity evaluation of [(2,4-dichlorophenoxy)methyl]-5-aryl-1,3,4-oxadiazole/4$H$-1,2,4-triazole analogues," Turkish Journal of Chemistry: Vol. 42: No. 5, Article 12. https://doi.org/10.3906/kim-1803-25
Available at: https://journals.tubitak.gov.tr/chem/vol42/iss5/12