Synthesis and cytotoxicity evaluation of [(2,4-dichlorophenoxy)methyl]-5-aryl-1,3,4-oxadiazole/4$H$-1,2,4-triazole analogues

Authors

MOHAMED JAWED AHSAN

DOI

10.3906/kim-1803-25

Abstract

We report herein the synthesis, characterization, and cytotoxicity evaluations of some newer oxadiazole and triazole analogues (5a-j). The cytotoxicity of all the title compounds were evaluated as per the National Cancer Institute protocol in a one-dose assay (10 $\mu $M) on nine different panels of 59 cancer cell lines. 2-$\{$5-[(2,4-Dichlorophenoxy)methyl]-1,3,4-oxadiazol-2-yl$\}$phenol (5e) showed the maximum cytotoxicity among the series of ten compounds. The cytotoxicity of 5e was comparable to that of the standard anticancer drug, 5-fluorouracil, and better than that of imatinib. The structure activity relationship was also discussed.

Keywords

Anticancer activity, cancer cell lines, cytotoxicity, one dose assay, oxadiazole, triazole

First Page

1334

Last Page

1343

Recommended Citation

AHSAN, MOHAMED JAWED (2018) "Synthesis and cytotoxicity evaluation of [(2,4-dichlorophenoxy)methyl]-5-aryl-1,3,4-oxadiazole/4$H$-1,2,4-triazole analogues," Turkish Journal of Chemistry: Vol. 42: No. 5, Article 12. https://doi.org/10.3906/kim-1803-25
Available at: https://journals.tubitak.gov.tr/chem/vol42/iss5/12