The interaction between a zinc(II) phthalocyanine compound bearing octakis phenoxyacetamide substituents and calf thymus DNA

Authors

ALİ ARSLANTAŞ
MEHMET SALİH AĞIRTAŞ

Abstract

In this study, a zinc(II) phthalocyanine compound (PcZn) substituted with octakis phenoxyacetamide was synthesized and characterized. Calf thymus DNA (CT-DNA) was used to determine the DNA binding properties of the zinc(II) phthalocyanine compound. This interaction of CT-DNA with PcZn was investigated using electronic absorption spectra, emission spectroscopy, a thermal melting temperature study, cyclic voltammetry, and viscosity measurements in a Tris-HCl buffer solution at a pH of 7.2. The findings showed that zinc(II) phthalocyanine interacts with calf thymus DNA via partial intercalative binding mechanisms. In addition to the techniques above, a gel electrophoresis study was also carried out to verify the interaction of CT-DNA with the PcZn complex. The results demonstrated that the octakis phenoxyacetamide-substituted zinc(II) phthalocyanine complex binds to CT-DNA via a partial intercalative binding mode.

DOI

10.3906/kim-1805-18

Keywords

DNA binding, absorption spectroscopy, gel electrophoresis, thermal melting, phthalocyanine compound

First Page

1310

Last Page

1320

Recommended Citation

ARSLANTAŞ, ALİ and AĞIRTAŞ, MEHMET SALİH (2018) "The interaction between a zinc(II) phthalocyanine compound bearing octakis phenoxyacetamide substituents and calf thymus DNA," Turkish Journal of Chemistry: Vol. 42: No. 5, Article 10. https://doi.org/10.3906/kim-1805-18
Available at: https://journals.tubitak.gov.tr/chem/vol42/iss5/10