The interaction between a zinc(II) phthalocyanine compound bearing octakis phenoxyacetamide substituents and calf thymus DNA

Authors

ALİ ARSLANTAŞ
MEHMET SALİH AĞIRTAŞ

DOI

10.3906/kim-1805-18

Abstract

In this study, a zinc(II) phthalocyanine compound (PcZn) substituted with octakis phenoxyacetamide was synthesized and characterized. Calf thymus DNA (CT-DNA) was used to determine the DNA binding properties of the zinc(II) phthalocyanine compound. This interaction of CT-DNA with PcZn was investigated using electronic absorption spectra, emission spectroscopy, a thermal melting temperature study, cyclic voltammetry, and viscosity measurements in a Tris-HCl buffer solution at a pH of 7.2. The findings showed that zinc(II) phthalocyanine interacts with calf thymus DNA via partial intercalative binding mechanisms. In addition to the techniques above, a gel electrophoresis study was also carried out to verify the interaction of CT-DNA with the PcZn complex. The results demonstrated that the octakis phenoxyacetamide-substituted zinc(II) phthalocyanine complex binds to CT-DNA via a partial intercalative binding mode.

Keywords

DNA binding, absorption spectroscopy, gel electrophoresis, thermal melting, phthalocyanine compound

First Page

1310

Last Page

1320

Recommended Citation

ARSLANTAŞ, ALİ and AĞIRTAŞ, MEHMET SALİH (2018) "The interaction between a zinc(II) phthalocyanine compound bearing octakis phenoxyacetamide substituents and calf thymus DNA," Turkish Journal of Chemistry: Vol. 42: No. 5, Article 10. https://doi.org/10.3906/kim-1805-18
Available at: https://journals.tubitak.gov.tr/chem/vol42/iss5/10