Turkish Journal of Chemistry
DOI
10.3906/kim-1709-4
Abstract
The tetrahydropyridine (THP) ring system has received considerable focus due to its excellent ability to act as a pharmacophore. It is recognized as a major constituent in natural alkaloids. THP derivatives have been reported for a diverse range of biological activities. Recent synthetic works contain syntheses of monosubstituted, disubstituted, trisubstituted, highly functionalized, and condensed structures. In this review, we summarize the recent literature dealing with the bioactive nature of this important heterocycle.
Keywords
Functionalized tetrahydropyridine, condensed tetrahydropyridine, multicomponent reaction, antimicrobial, antiinflammatory, anticancer, tryptamine receptor agonist, muscarinic receptor agonist, enzyme inhibitors
First Page
1191
Last Page
1216
Recommended Citation
MOHSIN, NOOR UL AMIN and AHMAD, MATLOOB
(2018)
"Tetrahydropyridine: a promising heterocycle for pharmacologically active molecules,"
Turkish Journal of Chemistry: Vol. 42:
No.
5, Article 1.
https://doi.org/10.3906/kim-1709-4
Available at:
https://journals.tubitak.gov.tr/chem/vol42/iss5/1
