A one-pot, environmentally friendly, and efficient protocol for the synthesis of novel polyfunctionalized benzo[$a$]pyrimido[5',4':5,6]pyrido[2,3-$c$]phenazine derivatives has been reported by a one-pot, four-component sequential reaction between 2-hydroxynaphthalene-1,4-dione, benzene-1,2-diamines, benzaldehydes, and 6-amino-1,3-dimethyluracil in the presence of $p$-TSA as a nontoxic, inexpensive, ecofriendly, and efficacious solid acid catalyst. Two C-C bonds, two C=N bonds, and one C-N bond, as well as two new rings, were formed in this reaction. Through this procedure, compounds with substantial biological and pharmaceutical properties are generated in a single operation. Factors such as high yields, less reaction time, operational simplicity, and lack of any dangerous reagents/solvents have made this process a green one.
Multicomponent reactions, microwave irradiation, $p$-TSA, benzo[$a$]pyrimido[5', 4':5, 6]pyrido[2, 3-$c$]phenazine
TABIBIAN, MAHDIEH; MOHEBAT, RAZIEH; and TABATABAEE, MASOUMEH
"A novel one-pot and rapid synthesis of polyfunctionalized benzo[a]pyrimido[5',4':5,6] pyrido[2,3-c]phenazine derivatives under microwave irradiation,"
Turkish Journal of Chemistry: Vol. 42:
4, Article 5.
Available at: https://journals.tubitak.gov.tr/chem/vol42/iss4/5