Spectroscopic and thermodynamic approach to the interaction of nonperipherally substituted cationic phthalocyanines with calf thymus (CT)-DNA

Authors

SEVGİCAN TUNCER
İBRAHİM ÖZÇEŞMECİ
BEHİCE ŞEBNEM SESALAN
AYFER KALKAN BURAT

Abstract

Novel, nonperipherally tetrasubstituted cationic metal-free and metallophthalocyanines (Zn, In) were synthesized in the present study. The binding constants, the disappearance of quenching effect of all cationic phthalocyanines on the fluorescence intensity of SYBR Green--disodium salt of deoxyribonucleic acid (DNA) from calf thymus complex, and the changes in T$_{m}$ of double helix DNA with thermal denaturation profile were investigated by UV-Vis and fluorescence spectrophotometric methods. To investigate the spontaneity of the reactions between DNA and novel quaternized phthalocyanines in buffer, thermodynamic parameters were employed.

DOI

10.3906/kim-1705-59

Keywords

Calf thymus (CT)-DNA, morpholine, quaternized phthalocyanines, Gibbs, entropy

First Page

274

Last Page

290

Recommended Citation

TUNCER, S, ÖZÇEŞMECİ, İ, SESALAN, B. Ş, & BURAT, A. K (2018). Spectroscopic and thermodynamic approach to the interaction of nonperipherally substituted cationic phthalocyanines with calf thymus (CT)-DNA. Turkish Journal of Chemistry 42 (2): 274-290. https://doi.org/10.3906/kim-1705-59