Synthesis, biological evaluation, and in silico study of some unique multifunctional 1,2,4-triazole acetamides

Authors

ALMAS SATTAR
AZIZ UR REHMAN
MUHAMMAD ATHAR ABBASI
SABAHAT ZAHRA SADDIQUI
SHAHID RASOOL
HIRA KHALID
MUHAMMAD ARIF LODHI
FARMAN ALI KHAN

DOI

10.3906/kim-1706-50

Abstract

The imperative demand for antibacterial agents and enzyme inhibitors prompted us to synthesize some new compounds, 6a-6k, bearing multifunctional moieties. The target acetamides were derived from 4-phenyl-5-(1-tosylpiperidin-4-yl)-4$H$-1,2,4-triazole-3-thiol (3). The structural analysis was carried out using modern spectroscopic techniques including IR, NMR, and EIMS spectral analysis. The antibacterial activity was screened against five bacterial strains including three gram-negative and two gram-positive ones. Enzyme inhibition was carried out against lipoxygenase enzyme and results were supported by in silico study. The synthesized compounds were proved to be potent antibacterial agents and enzyme inhibitors.

Keywords

1, 2, 4-Triazole, acetamides, antibacterial activity, lipoxygenase enzyme inhibition, in silico stud

First Page

401

Last Page

417

Recommended Citation

SATTAR, ALMAS; REHMAN, AZIZ UR; ABBASI, MUHAMMAD ATHAR; SADDIQUI, SABAHAT ZAHRA; RASOOL, SHAHID; KHALID, HIRA; LODHI, MUHAMMAD ARIF; and KHAN, FARMAN ALI (2018) "Synthesis, biological evaluation, and in silico study of some unique multifunctional 1,2,4-triazole acetamides," Turkish Journal of Chemistry: Vol. 42: No. 2, Article 16. https://doi.org/10.3906/kim-1706-50
Available at: https://journals.tubitak.gov.tr/chem/vol42/iss2/16