Abstract

Aliphatic nitroalkanes with different functional groups were synthesized from the Michael addition reactions of active methylene compounds 2 and nitrovinyl arenes 1 in high yields. The synthesized Michael adducts were subjected to intramolecular cyclization to give heteroaryl substituted γ-lactams in good to high yields under mild reaction conditions.

DOI

10.3906/kim-1705-25

Keywords

γ-Lactam, aliphatic nitroalkanes, Michael addition, nitrovinyl arenes

First Page

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Recommended Citation

ÇINAR, S, & ÜNALEROĞLU, C (2018). Facile synthesis of heteroaryl substituted -lactams from nitrovinyl arenes. Turkish Journal of Chemistry 42 (1): 29-35. https://doi.org/10.3906/kim-1705-25

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