Biological study on novel coumarinyl 1,3,4-oxadiazoles

Authors

MAJA MOLNAR
ANA AMIC
VALENTINA PAVIC
TIHOMIR KOVAC
MARIJA KOVAC
ELIZABETA HAS-SCHÖN

DOI

10.3906/kim-1703-2

Abstract

Coumarinyl 1,3,4-oxadiazoles were synthesized from Schiff bases and acetic anhydride. All compounds were characterized by melting points and their structures confirmed by mass and $^{1}$H and $^{13}$C NMR spectrometry. These novel coumarinyl derivatives were subjected to antibacterial, antifungal, anta atoxigenic, and antioxidant activity. Their activity varied depending on their structure, where 2-(3-acetyl-5-(((4-methyl-2-oxo-2H-chromen-7-yl)oxy)methyl)- 2,3-dihydro-1,3,4-oxadiazol-2-yl)-1,4-phenylene diacetate showed significant antioxidant and antibacterial activity on B. subtilis. 4-(3-Acetyl-5-(((4-methyl-2-oxo-2H-chromen-7-yl)oxy)methyl)-2,3-dihydro-1,3,4-oxadiazol-2-yl)-1,2-phenylene diacetate was found to possess excellent antifungal and antia atoxigenic activity.

Keywords

Coumarin, 1, 3, 4-oxadiazole, antibacterial, antifungal, antimycotoxigenic activity

First Page

146

Last Page

157

Recommended Citation

MOLNAR, MAJA; AMIC, ANA; PAVIC, VALENTINA; KOVAC, TIHOMIR; KOVAC, MARIJA; and HAS-SCHÖN, ELIZABETA (2018) "Biological study on novel coumarinyl 1,3,4-oxadiazoles," Turkish Journal of Chemistry: Vol. 42: No. 1, Article 13. https://doi.org/10.3906/kim-1703-2
Available at: https://journals.tubitak.gov.tr/chem/vol42/iss1/13