Synthesis of novel 5-substituted phenyl-3-(p-isopropylphenyl)-1-phenylformazan and their biological activities

Authors

AYŞE ŞAHİN YAĞLIOĞLU
HÜLYA ŞENÖZ

DOI

10.3906/kim-1612-42

Abstract

Novel 1-substituted 3-(p-isopropylphenyl)-5-phenylformazans (3a--g) were synthesized and characterized by elemental analysis, $^{1}$H NMR, and FT-IR techniques and UV-visible spectroscopy. Antiproliferative activities of 3a--g against HeLa and C6 cells were determined using the BrdU cell proliferation ELISA assay. 5-Florouracil was used as the positive control. The effects of substituents (--H, --CH$_{3}$, and --I) and their positions ($ortho$, $meta$, and $para$) on the antiproliferative activities were evaluated. The results of the assay indicate that I substituent exhibited higher activity against the cells at the $meta$ and $para$ positions than --CH$_{3}$ and --H substituents. 3a--g exhibited both high antiproliferative activities against C6 cells and noncytotoxicity. 3a--g may be anticancer drug candidates.

Keywords

Formazan, diazo coupling, antiproliferative activity, cytotoxic activity, HeLa cell, C6 cell

First Page

883

Last Page

891

Recommended Citation

YAĞLIOĞLU, AYŞE ŞAHİN and ŞENÖZ, HÜLYA (2017) "Synthesis of novel 5-substituted phenyl-3-(p-isopropylphenyl)-1-phenylformazan and their biological activities," Turkish Journal of Chemistry: Vol. 41: No. 6, Article 7. https://doi.org/10.3906/kim-1612-42
Available at: https://journals.tubitak.gov.tr/chem/vol41/iss6/7