Diastereoselective synthesis of novel 2,5-dioxopyrrolidine derivatives via biocatalytic domino reactions

Authors

SAADIEH MOHAJER
ROBABEH BAHARFAR

DOI

10.3906/kim-1612-45

Abstract

A series of novel 2,5-dioxopyrrolidines were synthesized by the one-pot reaction of coumarin-3-carboxylic acids 1 with thiourea derivatives and alkyl isocyanides in the presence of Fe$_{3}$O$_{4}$ NPs @ lipase as heterogeneous reusable nanobiocatalysts with high yields.

Keywords

Diastereoselective synthesis, 2, 5-dioxopyrrolidine derivatives, biocatalytic reactions

First Page

502

Last Page

513

Recommended Citation

MOHAJER, SAADIEH and BAHARFAR, ROBABEH (2017) "Diastereoselective synthesis of novel 2,5-dioxopyrrolidine derivatives via biocatalytic domino reactions," Turkish Journal of Chemistry: Vol. 41: No. 4, Article 4. https://doi.org/10.3906/kim-1612-45
Available at: https://journals.tubitak.gov.tr/chem/vol41/iss4/4