Synthesis, characterization, and antimicrobial activities of novel monosaccharide-containing Schiff base ligands

Authors

FATMA TELLİ
STEPHEN THOMAS ASTLEY
AZİZE YEŞİM SALMAN

DOI

10.3906/kim-1606-76

Abstract

Four new chiral Schiff base ligands (3a-4a, 3b-4b) have been prepared using aminoisopropylidene derivatives of glucose and aminochloralose derivatives of mannose. The synthesized compounds 1 and 2 were characterized by nuclear magnetic resonance ($^{1}$H and $^{13}$C NMR), Fourier transform infrared spectroscopy (FTIR), UV/visible spectroscopy, and elemental analysis. A total of eight Schiff base compounds (3a-6a, 3b-6b) were tested for antimicrobial activity against Escherichia coli ATCC 12228, Staphylococcus aureus ATCC 6538, Klebsiella pneumoniae CCM 2318, Pseudomonas aeruginosa ATCC 27853, Salmonella typhimurium CCM 5445, Enterococcus faecalis ATCC 29212, Bacillus subtilis ATCC 6633, and Candida albicans ATCC 10239 and exhibited a range of activities.

Keywords

Chloralose, ONO-tridentate chiral Schiff base, amino sugar, antimicrobial activity

First Page

370

Last Page

380

Recommended Citation

TELLİ, FATMA; ASTLEY, STEPHEN THOMAS; and SALMAN, AZİZE YEŞİM (2017) "Synthesis, characterization, and antimicrobial activities of novel monosaccharide-containing Schiff base ligands," Turkish Journal of Chemistry: Vol. 41: No. 3, Article 6. https://doi.org/10.3906/kim-1606-76
Available at: https://journals.tubitak.gov.tr/chem/vol41/iss3/6