The structure and cytotoxic activity of a new saponin: cephoside A from Cephalaria elazigensis var. purpurea

Authors

PEYKER KAYCE
NAZLI BOKE SARIKAHYA
MURAT PEKMEZ
NAZLI ARDA
SUHEYLA KIRMIZIGUL

DOI

10.3906/kim-1607-68

Abstract

Investigation of the aerial parts of Cephalaria elazigensis var. purpurea afforded one new oleanane-type saponin, namely cephoside A (1), and five known natural compounds (2-6). Compound 2, named anemoclemoside A, which is an unusual triterpene glycoside, was identified in the family Dipsacaceae for the first time. Chemical structures of all compounds were determined on the basis of the HRESIMS and 1D and 2D NMR data. Cephoside A (1) and anemoclemoside A (2) were assessed for their cytotoxic activities against HeLa cells, having IC$_{50}$ values of 495 and 135 $\mu $g/mL, respectively.

Keywords

Cephoside A, Dipsacaceae, triterpene saponin, iridoid glycoside, cytotoxic activity, Cephalaria, anemoclemoside A

First Page

345

Last Page

353

Recommended Citation

KAYCE, PEYKER; SARIKAHYA, NAZLI BOKE; PEKMEZ, MURAT; ARDA, NAZLI; and KIRMIZIGUL, SUHEYLA (2017) "The structure and cytotoxic activity of a new saponin: cephoside A from Cephalaria elazigensis var. purpurea," Turkish Journal of Chemistry: Vol. 41: No. 3, Article 4. https://doi.org/10.3906/kim-1607-68
Available at: https://journals.tubitak.gov.tr/chem/vol41/iss3/4