Stereoselective and regioselective synthesis of $N$-substituted methyl 2-((azolyl)methyl)-3-arylacrylates from Baylis-Hillman acetates

Authors

AYŞEN KÖSECELİ ÖZENÇ
İLHAMİ ÇELİK
ŞULE KÖKTEN

DOI

10.3906/kim-1607-35

Abstract

$N$-Substituted methyl 2-((azolyl)methyl)-3-arylacrylates were synthesized stereo- and regioselectively with one-pot reaction between Baylis--Hillman acetates and a suitable acylazole in the presence of K$_{2}$CO$_{3}$ as a base catalyst. The targeted $N$-substituted azole acrylates were efficiently obtained in good yields (39%-89%).

Keywords

Imidazole, benzimidazole, benzotriazole, Baylis-Hillman acetates, $N$-substituted azole acrylates

First Page

323

Last Page

334

Recommended Citation

ÖZENÇ, AYŞEN KÖSECELİ; ÇELİK, İLHAMİ; and KÖKTEN, ŞULE (2017) "Stereoselective and regioselective synthesis of $N$-substituted methyl 2-((azolyl)methyl)-3-arylacrylates from Baylis-Hillman acetates," Turkish Journal of Chemistry: Vol. 41: No. 3, Article 2. https://doi.org/10.3906/kim-1607-35
Available at: https://journals.tubitak.gov.tr/chem/vol41/iss3/2